Exercise and Autism

Autistic individuals are prone to obesity even from before they are born. Studies now show that children of women who are both obese and diabetic during pregnancy are three to four times as likely to develop autism. To make matters worse, children born to diabetic mothers are themselves more likely to become diabetics and obese at young ages. This vicious cycle only seems to get worse for autistic individuals as later on in life the effects of inactivity and medications also makes them prone to obesity and diabetes.  It stands to reason that instituting some type of exercise program in this patient population should help forestall future health concerns. This has important secondary benefits, as exercise enhances  learning abilities, as well as our capacity to handle stress, anxiety and depression.

According to the California Department of Education, physically fit kids performed better on academic testing, even when controlling for socioeconomic status. Indeed, according to an article published in the Journal of Sport and Exercise Psychology in 2007 entitled “Physical fitness and academic achievement in 3rd and 5th grade students”, the body mass index (BMI) and aerobic fitness of children is associated with academic performance. The reason for this comes from basic science. In one such study, a group of mice were allowed to exercise in a training wheel while another group of mice were not allowed to partake in this activity. Mice who exercised were better than the sedentary ones at finding a hidden platform in an opaque pool . The mice who exercised had increased “neurotrophins” and bigger brains upon dissection at the end of the study. The area most noticeable changed was the hippocampus; a brain region famously known for its role in learning and memory.  These neurotrophins are not chemicals that carry out signaling but rather, they are chemicals that build and maintain brain circuitry. In other words, neurotrophins are important in maintaining the infrastructure of the brain.

What type of exercise is best for learning? Studies indicate that the best type of exercise for this purpose is that which mixes cardio with complex motor and balance requirements. Figure skating nicely fits the bill; however, I would include salsa dancing as probably my favorite.

Another benefit of exercise is its ability to control the emotional and physical feelings of stress. Exercise works at the cellular level to increase neurotrophins (see above), neurotransmitters, and insulin receptors.  During exercise muscle fibers in our bodies are broken and then pieced back together in a more robust fashion. Exercise even changes the proportion of  different types of muscle fiber, whether fast or slow twitching. The same thing happens with brain neurons and exercise, it makes you grow new cells and connections!

Multiple studies have now shown that rigorous exercise works to reduce anxiety.  According to John Ratey, a psychiatrist and best-selling author, “Going for a run is like taking a little bit of Prozac and a little bit of Ritalin.” Cardiologist Carl “Chip” Lavie has over 70 articles published on exercise and the heart, 11 of which focus on anxiety. All of them have shown marked improvements in mood. Other studies have shown no difference between medication and exercise in their effect on depression. The positive effects of exercise on mood occurs regardless of whether the same happens at home or in a supervised setting.

Exercise may have another major benefit for autistic individuals. In 2003, German scientists compared executive functions before and after exercise (30 min stationary bike at either 40 or 60% maximum heart rate) in healthy and mildly depressed individuals. Those with mild depression showed improvements in executive functions at both intensity levels. Executive functions appear deficient in many autistic individuals and, according the aforementioned study, could be somewhat improved by exercise.

Exercise should be considered the first stage of intervention in the treatment of any mild mood disorders. Psychologically, it gives the person proof that they can take the initiative to change themselves. In the end, they may begin to feel better because they are effectively doing their own behavioral therapy.  Exercise offers all of the positive effects and none of the side effects of medications.

If you decide to do exercise, remember to be patient. It takes about 3 weeks for antidepressants to work, and an equal amount of time for exercise to cause cells to grow in the brain and establish new connections. Also, there is a minimum amount of time you need to invest for positive effects to emerge. The literature suggests a minimum of 30 minutes 3 times per week, but personally I recommend 30 minutes 5 times per week.

Related posts:

Autism the usefulness of exercise: https://corticalchauvinism.com/2014/09/01/autism-the-usefulness-of-exercise/

Autism and the sedentary life: https://corticalchauvinism.com/2017/10/09/autism-and-the-sedentary-life/

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3 responses to “Exercise and Autism

  1. FGFs Baby!!! Oh yeah, and BDNF too, but I’m in Camp FGFs

    In terms of regulation of neurogenesis in the hippocampus, which helps with memory formation and emotional control, FGF2 is released by exercise . Additionally, FGF21 is released by both muscle and liver. It is released in response to exercise. From liver, it is expressed after ingestion of sweet foods (in rodent studies) and leads to the suppression of craving for sweet foods. One of the primary receptors for FGF, FGFR1, is strongly expressed not only by the hippocampus, that helps to negatively regulate the HPA axis (aka cortizol/stress hormone pathway) as well as in hypothalamic tanycytes, a specialized form of astrocyte support cell. Those tanycytes are very important for the transfer of chemical and hormonal messages to the hypothalamus. The hypothalamus regulates feeding behavior and hormonal control.

    Liked by 1 person

  2. Re Karen’s comment, most babies don’t do much eating or running or weightlifting before they’re born so appetite and exercise factors are unlikely to explain obesity before birth. But here’s what can.

    Mercury is well-established as impairing thyroid function; by zapping selenoenzymes it reduces the production of T4 and also reduces its conversion to T3. Impaired T4/T3 levels are well-established as causing overweight. Thus mercury is well-understood as a causal factor in overweight.

    Conclusive evidence has already been presented that mercury has been the main factor in autism causation in recent decades – Chapter 3 at http://www.pseudoexpertise.com .

    So there’s a simple causality: the mercury which causes the autism also causes pre-birth overweight. This is of course yet more evidence in support of the mercury-autism causation theory.

    Like

  3. Pingback: Maternal Health, Diabetes and Autism | Cortical Chauvinism·

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