Our latest publication detailing networks of genes implicated in autism and intellectual disability.
Last week our team published its newest work in the realm of autism genetics in Frontiers in Psychiatry titled, “Widespread Genotype-Phenotype Correlations in Intellectual Disability.” For those of you who don’t follow genetics closely, that title probably means little to you. So I’m going to try to explain what we found and why we think it’s so interesting.
This work was performed in conjunction with one of my primary collaborators, Dr. Alex Feltus at Clemson University and one of his students, Zach Gerstner. We took a large group of genes associated with intellectual disability (mental retardation) and divided them into subgroups based on whether the conditions had the following clinical features:
- high co-occurring rates of autism
- high co-occurring rates of epilepsy
- association with different types of facial malformations
- association with neurodegeneration or other neurodegenerative features like brain atrophy and certain movements disorders
CFD = complex (multiple) facial malformations; SFD =…
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