- For patients with suspected bacterial infection, clinicians should generally not start antibiotics until they have obtained blood, urine, or other cultures.
- Broad-spectrum antimicrobials shouldn’t be used for perioperative prophylaxis in uncomplicated clean and clean-contaminated procedures because they carry risks and have not been shown to be more beneficial than narrow-spectrum antibiotics. Additionally, perioperative prophylaxis should not continue after the incision is closed.
- Antibiotic therapy broader than ampicillin should be avoided in otherwise healthy, immunized, hospitalized patients with uncomplicated community-acquired pneumonia.
- Empirical vancomycin or carbapenem use should be avoided in neonatal intensive care patients unless the infant has a risk for organisms resistant to narrower-spectrum agents.
- Peripherally inserted central catheters or prolonged IV antibiotics shouldn’t be used in otherwise healthy children with infections if they can switch to an oral antimicrobial drug.
American Academy of Pediatrics- Committee on Infectious Diseases and the Pediatric Infectious Diseases Society (includes link to downloadable pdf)
Autism: Antibiotics and the Microbiome